“As a result, this generation will be held responsible for the murder of all God’s prophets from the creation of the world— from the murder of Abel to the murder of Zechariah, who was killed between the altar and the sanctuary. Yes, it will certainly be charged against this generation” (Luke 11:50-51 NLT).

WHY THIS GENERATION WAS HELD RESPONSIBLE
Jesus told the religious leaders of his day that their generation would be held responsible for all the prophets that God had sent them since creation. Why would God hold this generation responsible for all the prophets before them being murdered?
 
Jesus summarized the list of prophets killed beginning with Abel, whose murder was recorded in the first book, Genesis, and ending with the murder of Zechariah, whose stoning was recorded in 2 Chronicles, the last book according to the order of the Hebrew Bible. The first murder victim, Abel, was killed by his brother because he had “by faith offered a more acceptable sacrifice than Cain” (Heb. 11:4). Abel brought the firstborn of his flock as a sacrifice of blood, which in effect prophetically pointed to its fulfillment in Christ. God accepted Abel’s offering, but rejected Cain’s. And Cain murdered his own brother out of jealousy.
 
The last prophet recorded as being murdered in the Hebrew Bible was Zechariah, the son of the high priest, Jehoiada. King Joash conspired to have him stoned to death in the Temple courts because he had prophesied against him for forsaking the daily sacrifices and turning to idolatry (2 Chron. 24:15-22).
 
God had delayed His judgment against the Jews, so that the coming of the promised Seed, the Messiah, Jesus Christ, might be given to them and through them to the whole world. But this generation would reject and murder the very One to whom all the murdered prophets had pointed. And upon them God’s accumulated wrath would be spent. Indeed, this generation saw the fall of Jerusalem by the Romans in 70 AD, so that those that remained were dispersed among the nations.